The Application of ^99mTc-DTPA Renal Dynamic Imaging to Measuring Renal Function of Children with Acute Lymphoblastic Leukemia after Induction Therapy

Table 1

The patients’ demographic characteristics.

Characteristic	Non-AKI	AKI	value
Number of patients ()	81	21	—
Age (years) (median (IQR))	4.70 (3.08-7.83)	7.75 (5.17-11.17)	0.016^b
Gender (male/female) ()	47/34	15/6	0.262^c
Body weight (kg) (median(IQR))	17.50 (14.00-23.50)	26.00 (18.25-30.00)	0.008^b
Height (cm) (mean (SD))	111.75 (23.55)	124.62 (22.32)	0.026^a
Moderate risk/high risk ()	47/34	12/9	0.942^c
eGFR (ml/min per 1.73 m^2) (mean (SD))	226.39 (51.58)	222.76 (43.29)	0.768^a
Standardized GFRGates (ml/min per 1.73 m^2) (mean (SD))	215.59 (79.76)	168.10 (67.13)	0.014^a
Dosage/m^2 (g) (median (IQR))	4.92 (4.25-5.14)	4.75 (4.35-4.98)	0.331^b
Serum creatinine (μmol/l) (median (IQR))	22.60 (19.15-31.40)	26.80 (22.55-32.90)	0.085^b
ALT (U/l) (median (IQR))	16.0 (11.0-27.0)	17.0 (11.5-37.0)	0.469^b
ALB (g/l) (mean (SD))	45.34 (4.57)	45.08 (4.19)	0.816^a
Hydration on the first day of HDMTX (ml/m^2) (mean (SD))	3392 (597)	3562 (751)	0.274^a
Patients with urine on the first day of HDMTX, (%)	76 (93.8)	18 (85.7)	0.437^c
MTX24h (μmol/l) (mean (SD))	58.02 (21.42)	81.90 (30.34)	≤0.001^a
MTX48h (μmol/l) (median (IQR))	0.49 (0.35-0.86)	5.21 (3.37-19.65)	≤0.001^b
MTX72h (μmol/l) (median (IQR))	0.11 (0.07-0.18)	1.94 (0.76-6.35)	≤0.001^b

^aNormally distributed continuous variables were reported as means with standard deviations (SD) and compared with Student’s -test. ^bNonnormally distributed continuous variable data were reported as medians with interquartile range (IQR) and compared with Mann–Whitney test. ^cCategorical data were reported as proportions ( with %) and compared using chi-squared test. eGFR was calculated with the Schwartz equation.