BioMed Research International

Research Article

Hepatoprotective Activity of Leptadenia hastata (Asclepiadaceae) on Acetaminophen-Induced Toxicity in Mice: In Vivo Study and Characterization of Bioactive Compounds through Molecular Docking Approaches

Table 3

Calculated ADME, pharmacokinetic parameters, and drug-likeness parameters for the docked compounds.
Pharmacokinetic parametersDrug-likeness parameters (number of violations)
GI absorptionBBB permeantP-gp substrateCyp P450 inhibitorsSkin permeation (log Kp)LipinskiGhoseVeberEganMueggeBioavailability score
Cyp 1A2Cyp 2C19Cyp 2C9Cyp 2D6Cyp 3A4
QuinineHighYesNoNoNoNoYesNo-6.23 cm/sYes (0)YesYesYesYes0.55
DihydroxycoumarinHighNoNoNoNoNoNoNo-7.44 cm/sYes (0)YesYesYesYes0.55
ScopoletinHighYesNoYesNoNoNoNo-6.39 cm/sYes (0)YesYesYesNo (1)0.55
SilibininLowNoNoNoNoNoNoYes-7.89 cm/sYes (0)No (1)No (1)No (1)No (1)0.55