PCK1 Deficiency Shortens the Replicative Lifespan of Saccharomyces cerevisiae through Upregulation of PFK1

<div>PCK1-deficient S. cerevisiae enhanced the ROS levels through impacting glucose metabolism. (a)–(d) The production of glucose, pyruvic acid, citrate, and lactate level were examined in BY4742 and pck1Δ strain. (e)∼(h) The production of glucose, pyruvic acid, citrate, and lactate level was examined in BY4742 and PCK1 OE strain. 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(i) The ROS level of PCK1-deficient S. cerevisiae.</div>

BioMed Research International

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Figure 2

Figure 2: PCK1 Deficiency Shortens the Replicative Lifespan of Saccharomyces cerevisiae through Upregulation of PFK1