Beneficial Effects of Crocin against Depression via Pituitary Adenylate Cyclase-Activating Polypeptide

Figure 1

Crocin reversed the decreases of body weight and elevation of serum CORT. (a) Schematic diagram of the experimental process of chronic unpredictable mild stress (CUMS) program and treatments. (b) Weight change in 0-7 weeks’ model process. From the first week to 7th week: two-way ANOVA, , ; , ; , . All data are expressed as . , compared with the control group. (c, d) The weight and levels of CORT change. ANOVA, , ; , . All data are expressed as . , versus saline; , versus CUMS.

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