Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection

Figure 6

Immunohistochemical detection of MMP9 in the epithelium (EP) (yellow arrows indicate ciliated cells), as well as in tissue of the lamina propria (LP) from tracheal scars posttreatment with WHMs. Light brown immunostaining shows the mild expression of MMP9. (a) Presurgery tissue, (b) group I (control), (c) group II (hyaluronic acid), (d) group III (collagen-PVP), (e) group IV (mixture of hyaluronic acid+collagen-PVP), and (f) group V (mitomycin C). (g) Tracheal tissue as a negative control. (h) The canine lung was the positive control.

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