Machine Learning Supports Long Noncoding RNAs as Expression Markers for Endometrial Carcinoma

Figure 2

Differentially expressed genes highlighted. (a) Volcano plot of the differential expression analysis of total RNA in primary tumor (TP) compared with adjacent tissue (NT). TP upregulated transcripts (67 genes) with log fold change (logFC) > 5 (red). TP downregulated transcripts with logFC < −5 (124 genes) (green). Horizontal purple line indicates the −log10 (FDR) = 2 (FDR = 0.01) cutoff. Grey vertical lines indicate logFC = −5 and logFC = 5 cutoffs. (b) Heat map of the expression of the 50 most differentially expressed transcripts. Dendrogram: the clustering of TP samples (sky blue); the clustering of NT samples (purple). Top left: colorkey for the heat expression quantification.

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