FITC-Labeled Alendronate as an In Vivo Bone pH Sensor

Figure 4

Application of Aln-FITC in sensing pH changes in a metabolic acidosis model. (a) In vivo fluorescent images of Aln-FITC in nude mice during three different states: the normal state, metabolic acidosis state, and alkaline drug treatment state. (b, c) Quantitative calculation of relative radiant efficiency and corresponding pH change of the skull (red), limbs (black), and pelvis (blue) under the three different conditions.

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