Protective Effect of Methylxanthine Fractions Isolated from Bancha Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats

Figure 5

Photomicrographs of muscle sections of left ventricular chambers stained with H&E ×400. (a) Control; normal myofibrilar architecture. (b) Doxorubicin-treated group (cumulative dose: 20 mg/kg); disorganization of cardiac muscle fibres (arrow left), cytoplasmic fading, and pyknotic nucleus formation (arrow above) and myofibril ruptures (arrow right). (c) A group pretreated with MXB (5 mg/kg); ameliorated myofibrilar disorganization.

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