A Five-Gene Signature for Recurrence Prediction of Hepatocellular Carcinoma Patients

Table 2

Univariate and multivariate analyses of risk factors related to RFS in HCC patients.

Clinical factor	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Gender (male vs. female)	0.656	0.300-1.440	0.294
Age	0.999	0.977-1.022	0.940
ALT (<=50 U/L vs. >50 U/L)	1.022	0.617-1.694	0.931
Main tumor size(<=5 cm vs. >5 cm)	1.620	0.958-2.740	0.072
Multinodular (no vs. yes)	1.556	0.871-2.782	0.135
Cirrhosis (no vs. yes)	3.428	0.838-14.022	0.087
AVR-CC (no vs. yes)	0.700	0.386-1.269	0.240
CLIP stage (0 vs. 1-5)	0.848	0.517-1.391	0.514
TNM stage (I+II vs. III+IV)	1.758	1.242-2.489	0.001	1.359	0.906-2.038	0.138
BCLC stage	2.586	1.545-4.331	<0.001	1.926	1.070-3.469	0.029
AFP (<=300 ng/ml vs. >300 ng/ml)	0.784	0.477-1.287	0.335
Risk score	1.316	1.161-1.491	<0.001	1.313	1.153-1.497	<0.001

Abbreviations: AVR-CC: active viral replication chronic carrier; ALT: alanine aminotransferase; TNM: tumor node metastasis; CLIP: cancer liver Italian program; BCLC: Barcelona Clinic Liver Cancer; AFP: alpha-fetoprotein.