Chitosan-Based Delivery of Avian Reovirus Fusogenic Protein p10 Gene: In Vitro and In Vivo Studies towards a New Vaccine against Melanoma

Figure 3

In vivo antitumor effect of NP-ARV against melanoma. Mice were challenged with viable B16 cells and monitored daily until tumor size reached its maximum. (a) Experiment timeline. (b) Schematic representation of the experiment strategy. (c) Tumor growth of the nontreated control group (open circles), chitosan alone group (gray circles), and NP-ARV group (black circles). The vertical line at day 10 indicates the day at which the last control mouse reached the MTV. The experiment was done in 5-6 animals for each group and graphed individually.

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