Mesenchymal Stem Cells Activate the MEK/ERK Signaling Pathway and Enhance DNA Methylation via DNMT1 in PBMC from Systemic Lupus Erythematosus

Figure 3

BM-MSC alter the expression of methylation-sensitive genes of SLE PBMC. PBMC were cultured in the same procedure as in Figure 2 for 5 days. The mRNA levels of methylation-sensitive genes including CD70, selectin-l, IL-13, ITGAL, perforin, and IL-4 of PBMC from healthy controls and SLE patients were measured by real-time PCR. The data are presented as the of 6 healthy volunteers and 6 patients. , , and .

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