Dysregulated Bone Metabolism Is Related to High Expression of miR-151a-3p in Severe Adolescent Idiopathic Scoliosis

Figure 1

Differentially expressed miRNAs in plasma from severe, mild scoliosis and healthy controls. (a) miRNA sequencing was performed in severe AIS, mild AIS, and healthy control groups, and each group has five samples. In total, 32 significantly differentially expressed miRNAs were represented in the heat map. Hierarchical clustering analysis revealed that two major clusters exist between the three groups. Pink and blue represent upregulated and downregulated expressions, respectively. (b) Venn diagram revealed the convergence of differentially expressed miRNAs between comparisons. S AIS represents the severe AIS group, M AIS represents the mild AIS group, and NC represents the healthy control group. (c) Heat map of differentially expressed miRNAs between the severe AIS and healthy control groups. Pink and blue represent upregulated and downregulated expressions, respectively. (d) Heat map of differentially expressed miRNAs between the severe AIS and mild AIS groups. Pink and blue represent upregulated and downregulated expressions, respectively.

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