Coexpression Network Analysis Identifies a Novel Nine-RNA Signature to Improve Prognostic Prediction for Prostate Cancer Patients

Table 2

The optimal prognostic signature.

Symbol	Module	Expression	Type	Univariate Cox regression			Multivariate Cox regression			LASSO coefficient
				HR	95% CI	value	HR	95% CI	value
GINS2	Green	Upregulated	mRNA	3.248	1.344-7.849	4.450E-03	1.399	1.261-2.036	3.33E-02	1.4561
NLGN2	Yellow	Downregulated	mRNA	6.514	1.237-14.31	1.350E-02	3.012	2.000-9.079	2.10E-02	1.7956
EBNA1BP2	Blue	Upregulated	mRNA	7.112	1.048-18.28	2.250E-02	4.470	2.904-12.115	2.79E-02	2.7422
DLG5-AS1	Blue	Downregulated	lncRNA	0.629	0.199-0.987	3.655E-02	0.589	0.290-0.931	4.59E-02	-0.2216
MAGI2-AS3	Yellow	Downregulated	lncRNA	0.354	0.0572-0.914	2.210E-02	0.512	0.220-0.913	4.51E-02	-0.7093
RHPN1-AS1	Green	Upregulated	lncRNA	0.272	0.0286-0.581	2.210E-02	0.513	0.236-0.711	3.89E-02	-1.5300
MELK	Green	Upregulated	mRNA	0.557	0.047-0.625	1.950E-02	0.360	0.110-1.179	3.84E-02	-0.0482
EIF5AL1	Blue	Upregulated	mRNA	0.194	0.0311-0.414	4.000E-02	0.540	0.273-0.701	3.26E-02	-1.5588
G6PC3	Blue	Upregulated	mRNA	0.237	0.0617-0.912	1.800E-02	0.352	0.1117-0.509	2.66E-02	-1.5551

HR: hazard ratio; CI: confidence interval; LASSO: least absolute shrinkage and selection operator.