Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?

Figure 2

Three-dimensional model of the viroporin-like tetrameric assembly of the E protein from Sars-CoV-2 represented as a cartoon model. Residues corresponding to the mutated sites indicated in Figure 1 are displayed as transparent space-filling spheres and labelled with the amino acid one-letter code. The C-terminal segments of the model are reported for completeness. However, they convey no structural information due to lack of a corresponding segment in the structural template used in homology modelling. Structure in panel (b) is rotated by approximately 180° along the axis with respect to the orientation shown in panel (a).

(a)

(b)