Ensemble Learning Prediction of Drug-Target Interactions Using GIST Descriptor Extracted from PSSM-Based Evolutionary Information

Table 3

5-fold cross-validation results were generated through the proposed method on the ion channel dataset.

Testing set	Accuracy (%)	Precision (%)	Sensitivity (%)	MCC (%)	AUC	AUPR
1	85.59	86.76	84.12	75.33	0.9292	0.8435
2	86.95	87.63	86.15	77.30	0.9431	0.8686
3	87.63	88.18	87.29	78.31	0.9323	0.8633
4	85.59	83.16	87.59	75.31	0.9370	0.8056
5	83.90	86.01	81.73	72.96	0.9146	0.8287
Average	85.93 ± 1.44	86.35 ± 1.96	85.38 ± 2.45	75.84 ± 2.07	0.9312 ± 0.0107	0.8419 ± 0.0258