Ensemble Learning Prediction of Drug-Target Interactions Using GIST Descriptor Extracted from PSSM-Based Evolutionary Information

Table 5

5-fold cross-validation results were generated through the proposed method on the nuclear receptor dataset.

Testing set	Accuracy (%)	Precision (%)	Sensitivity (%)	MCC (%)	AUC	AUPR
1	75.00	76.92	62.50	60.78	0.7688	0.6444
2	80.56	78.95	83.33	68.62	0.8148	0.7007
3	69.44	81.25	61.90	56.69	0.8254	0.8484
4	72.22	60.00	85.71	58.61	0.8442	0.7507
5	72.22	72.00	85.71	56.06	0.7524	0.7053
Average	73.89 ± 4.21	73.82 ± 8.45	75.83 ± 12.48	60.15 ± 5.08	0.8011 ± 0.0389	0.7299 ± 0.0762