The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium

Table 1

NMBA-induced statistics of lesions in esophageal epithelial carcinogenesis in mice (mean ± SD).

Time (w)	Group	Number	Simple hyperplasia	Mild atypical dysplasia	Moderate atypical dysplasia	Sever atypical dysplasia
16	Loxp mice	3	4.30 ± 3.79	0	0	0
	KO mice	5	9.20 ± 5.26	2.20 ± 2.68	0	0
48	Loxp mice	13	8.62 ± 6.17	1.07 ± 1.93	0	0
	KO mice	14	13.43 ± 7.9	6.64 ± 5.87	1.57 ± 4.54	0.71 ± 1.86