Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma

Figure 4

The genome-wide methylation pattern of APOBEC3H in HNSC. (a) The heatmap of APOBEC3H-associated methylation genes (columns, individual samples; rows, CpG sites; red, high methylation levels; blue, low methylation levels). (b) The pie chart of the ratios of hypomethylation and hypermethylation sites. (c) The proportion of differently methylated CpG site distribution according to the genome. (d) The proportion of differently methylated CpG site distribution according to the CpG island. Biological process (e), cell composition (f), and molecular function of the GO annotations (g) of APOBEC3H-associated methylation genes.

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