[Retracted] Circular RNA circCCDC66 Contributes to Malignant Phenotype of Osteosarcoma by Sponging miR-338-3p to Upregulate the Expression of PTP1B

Figure 6

circCCDC66 increased PTP1B expression by sponging and inhibiting miR-338-3p in OS. (a) Knockdown of miR-338-3p significantly enhanced PTP1B expression in OS cells. (b) miR-338-3p overexpression decreased the luciferase activity of both SW1353 and U2OS cells transfected by PTP1B-WT. (c) Knockdown of circCCDC66 or the upregulation of miR-338-3p can inhibit the expression of PTP1B mRNA. (d) Relative luciferase activities of 293 T cells cotransfected with PTP1B 3-UTR-MUT, PTP1B 3-UTR-WT and Mock, si-circCCDC66, miR-NC, or miR-338-3P vector were analyzed through luciferase reporter experiments. , .

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