Research Article
The PARK2 Mutation Associated with Parkinson’s Disease Enhances the Vulnerability of Peripheral Blood Lymphocytes to Paraquat
Table 2
Clinical features of patients with PARK2 C441R mutation.
| Clinical feature | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 |
| Sex | Woman | Man | Man | Man | Man | Age at disease onset (years) | 23 | 34 | 32 | 20 | 40 | Disease duration (years) | 2 | 2 | 6 | 7 | 10 | Bradykinesia | + | + | + | + | + | Rigidity | + | + | + | + | + | Resting tremor | — | — | + | + | + | Postural tremor | — | — | + | + | — | Shuffling gait | — | — | — | + | + | Postural instability | — | — | — | + | — | Hyperreflexia | — | + | — | + | — | Diurnal fluctuations | — | — | — | + | + | Foot dystonia | — | + | — | + | + | Hoehn and Yahr stage at last examination (off state) | 1 | 1 | 2 | 2.5 | 2.5 | UPDRS III score at last exam (off state) | 12 | 15 | 19 | 22 | 27 |
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