The PARK2 Mutation Associated with Parkinson’s Disease Enhances the Vulnerability of Peripheral Blood Lymphocytes to Paraquat

Table 2

Clinical features of patients with PARK2 C441R mutation.

Clinical feature	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
Sex	Woman	Man	Man	Man	Man
Age at disease onset (years)	23	34	32	20	40
Disease duration (years)	2	2	6	7	10
Bradykinesia	+	+	+	+	+
Rigidity	+	+	+	+	+
Resting tremor	—	—	+	+	+
Postural tremor	—	—	+	+	—
Shuffling gait	—	—	—	+	+
Postural instability	—	—	—	+	—
Hyperreflexia	—	+	—	+	—
Diurnal fluctuations	—	—	—	+	+
Foot dystonia	—	+	—	+	+
Hoehn and Yahr stage at last examination (off state)	1	1	2	2.5	2.5
UPDRS III score at last exam (off state)	12	15	19	22	27