Space Radiation Biology for “Living in Space”

Figure 2

Cell cycle-phasing capabilities of the Fucci technology. Cell cycle regulations involving E3 ligase activities of CUL4^Ddb1, SCF^Skp2, and APC^Cdh1. Molecules whose intracellular concentrations or enzymatic activities change in a cell cycle-dependent manner are shown in color. PCNA^DNA: DNA-bound PCNA. Data adapted from Sakaue-Sawano et al. [164].