Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload

Figure 1

Effect of MGCD0103 (MGCD) on systolic blood pressure and body weight in rats after transverse aortic constriction (TAC). (a) Systolic blood pressure (SBP) was measured using the tail-cuff method in the sham (), sham plus MGCD (), TAC (), and TAC plus MGCD groups () for five weeks. Administration of MGCD attenuated TAC-induced hypertension. (b) Rat body weights were monitored for four weeks. The body weights of TAC rats treated with or without MGCD were not affected. Data are shown as of eight rats per group ( vs. sham group, ^# vs. TAC group).

(a)

(b)