|
| Participant’s characteristics | Total | Women HBeAg (-) | Women HBeAg (+) | value |
|
| Maternal characteristics at baseline | | | | |
| Number of women with data | 183 | 141 | 42 | |
| Age (years), median (IQR) | 30 (26-33) | 30 (26-33) | 29 (26-34) | 0.59 |
| HBV infection known before pregnancy, (%) | 48 (26.2) | 24 (17.0) | 24 (57.1) | <0.001 |
| Partner’s HBV status, (%) | | | | |
| HBsAg positive | 13 (7.1) | 7 (5.0) | 6 (14.3) | 0.04 |
| HBsAg negative | 162 (88.5) | 126 (89.3) | 36 (85.7) |
| Does not known | 8 (4.4) | 8 (5.7) | 0 |
| Having family members infected with HBV, (%) | 23 (12.6) | 17 (12.1) | 6 (14.3) | 0.7 |
| ALT (U/L), median (IQR) | 32 (27-40) | 29 (25-36) | 91 (34-108) | <0.001 |
| HBV DNA level at 7th month of gestation, (%) | | | | |
| Detectable | 48 (26.2) | 14 (9.9) | 34 (81.0) | <0.001 |
| >200,000 IU/mL | 24 (13.1) | 2 (1.4) | 22 (52.4) | <0.001 |
| Maternal characteristics at delivery | | | | |
| Number of women with data | 183 | 141 | 42 | |
| Under HBV antiviral therapy in last 3 months, (%) | 31 (16.9) | 3 (9.7) | 28 (90.3) | <0.001 |
| Mode of delivery, (%) | | | | |
| Vaginal | 120 (65.6) | 95 (67.4) | 25 (59.5) | 0.35 |
| Caesarean | 63 (34.4) | 46 (32.6) | 17 (40.5) |
| HBV DNA level at delivery, (%) | | | | |
| Detectable | 37 (20.2) | 24 (17.0) | 13 (31.0) | 0.35 |
| ≥200,000 IU/mL | 6 (3.3) | 5 (3.5) | 1 (2.4) | 0.99 |
| Infant characteristics at birth | | | | |
| Number infants with data | 183 | 141 | 42 | |
| Sex—female, (%) | 88 (48.1) | 62 (44.0) | 26 (61.9) | 0.04 |
| Weight (kilograms), median (IQR) | 3.0 (2.8-3.2) | 2.9 (2.8-3.2) | 3.0 (2.8-3.3) | 0.46 |
| Child HBV birth dose vaccination, (%) | 181 (98.9) | 139 (98.6) | 42 (100.0) | 0.99 |
| Child HBIG immunization, (%) | 150 (82.0) | 116 (82.3) | 34 (81.0) | 0.85 |
| Positive HBsAg, (%) | 46 (25.1) | 27 (19.1) | 19 (45.2) | 0.001 |
| Infant characteristics at 6 months of age | | | | |
| Number infants with data | 176 | 135 | 41 | |
| Completed HBV vaccination schedule, (%) | 71 (40.3) | 51 (37.8) | 20 (48.8) | 0.21 |
| Infant feeding during the last 6 months, (%) | | | | |
| Breast-fed only | 90 (51.1) | 75 (55.6) | 15 (36.6) | 0.08 |
| Bottle-fed only | 73 (41.5) | 58 (38.5) | 22 (51.2) |
| Mixed (breast-fed and bottle-fed) | 13 (7.4) | 8 (5.9) | 5 (12.2) |
| Positive HBsAg, (%) | 23 (13.1) | 13 (9.6) | 10 (24.4) | 0.01 |
| Infant characteristics at 12 months of age | | | | |
| Number infants with data | 150 | 115 | 35 | |
| Completed HBV vaccination schedule, (%) | 142 (94.7) | 108 (93.9) | 34 (97.1) | 0.46 |
| Infant feeding during the last 6 months, (%) | | | | |
| Breast-fed only | 52 (34.7) | 42 (36.5) | 10 (28.6) | 0.24 |
| Bottle-fed (and/or other food) | 47 (31.3) | 32 (27.8) | 15 (42.8) |
| Mixed (breast-fed + bottle-fed and/or other food) | 51 (34.0) | 41 (35.7) | 10 (28.6) |
| Positive HBsAg, (%) | 12 (8.0) | 6 (5.2) | 6 (17.1) | 0.02 |
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