An UPLC-MS/MS Method for Simultaneous Quantification of the Components of Shenyanyihao Oral Solution in Rat Plasma

Table 1

Compounds identified in Shenyanyihao oral solution.

Identification	RT (min)	Formula	Herbs	Identification	RT (min)	Formula	Herbs
Arginine	0.61	C6H14N4O2	Chinese angelica	Isoquercitrin	11.94	C21H20O11	Hedyotis diffusa
Stachydrine	0.65	C7H13NO2	Herba leonuri	Dan phenolic acid B	11.99	C36H30O16	The root of red-rooted salvia
Rhamnose	0.65	C6H14O6	Hedyotis diffusa	Rosemary acid	12.35	C18H16O8	The root of red-rooted salvia
Glutamate	0.68	C5H9NO4	Chinese angelica	Baicalin	13.22	C21H18O11	Scutellaria baicalensis
Aspartic acid	0.69	C4H7NO4	Hedyotis diffusa	High front glycosides	14.68	C22H22O11	Plantain herb
Palmitic acid	0.79	C6H5NO2	Poria cocos	Digitalis glycosides	14.76	C31H40O15	Plantain herb
Uridine	1.06	C9H12N2O6	Agaric polyporus	Red sandalwood of trifoliate bean	15.00	C22H22O10	Pyrrosia lingua
Adenosine	1.13	C10H13N5O4	Agaric polyporus	Rhubarb phenol	15.13	C15H10O4	Agaric polyporus
Leucine	1.18	C6H13NO2	Chinese angelica	Han baicalin	15.18	C22H20O11	Scutellaria baicalensis
Guanosine	1.26	C10H13N5O5	Herba leonuri	Wood butterfly	16.28	C16H14O5	Scutellaria baicalensis
Phenylalanine	2.22	C9H11NO2	Herba leonuri	Celery	18.24	C15H10O5	Plantain herb
Hydroxymethylfurfural	2.41	C6H6O3	Codonopsis pilosula	Hispidulin	18.57	C16H12O6	Plantain herb
Syringic acid	2.96	C9H10O5	Herba leonuri	Salvia diol	21.49	C18H16O5	The root of red-rooted salvia
Danshensu	2.99	C9H10O5	The root of red-rooted salvia	Emodin methyl ether	23.81	C16H12O5	Agaric polyporus
Leonurine	3.18	C14H21NO4	Herba leonuri	2-Hydroxyflavones	23.88	C15H10O3	Agaric polyporus
Hydroxybenzaldehyde	3.22	C7H6O2	Agaric polyporus	Daidzein	24.17	C15H10O4	Agaric polyporus
Vanillic acid	3.22	C8H8O4	Chinese angelica	Methyl rosemary	24.90	C19H18O8	The root of red-rooted salvia
Caffeic acid	4.02	C9H8O4	The root of red-rooted salvia	Emodin methyl ether	24.92	C16H12O5	Agaric polyporus
Tryptophan	4.11	C11H12N2O2	Chinese angelica	Hydroxytanshinone	25.53	C19H18O4	The root of red-rooted salvia
Protocatechuic acid	4.54	C7H6O3	The root of red-rooted salvia	Stearic acid	26.88	C18H36O2	Plantain herb
Chlorogenic acid	5.43	C16H18O9	Pyrrosia lingua	Implicit tanshinone	26.91	C19H20O3	The root of red-rooted salvia
Aesculetin	6.52	C9H6O4	Chinese angelica	Dihydrotanshinone	27.09	C18H14O3	The root of red-rooted salvia
Rutin	9.39	C27H30O16	Pyrrosia lingua	Salvia miltiorrhiza new quinone	27.26	C18H16O3	The root of red-rooted salvia
Baicalein	10.10	C15H10O6	Hedyotis diffusa	Methyl salvianate	27.37	C20H18O5	The root of red-rooted salvia
Ferulic acid	10.32	C10H10O4	Chinese angelica	Tanshinone	27.64	C18H12O3	The root of red-rooted salvia
Scutellar	10.67	C21H18O12	Scutellaria baicalensis	Isocryptotanshinone	27.65	C19H20O3	The root of red-rooted salvia
Purple oxalic acid B	11.35	C27H22O12	The root of red-rooted salvia	Phthalic anhydride	27.87	C8H4O3	Chinese angelica