Engineered IL-7 Receptor Enhances the Therapeutic Effect of AXL-CAR-T Cells on Triple-Negative Breast Cancer

Figure 4

The tumor elimination in mice mediated by engineered CAR-T cells. Bioluminescence in vivo was collected by in vivo imaging starting from the time when mice were injected with tumor cells. (a) An image of the MDA-MB-231-luc allograft tumor in mice. (b) An image of the MCF-7-luc allograft tumor in mice. (c) Fluorescence intensity changes of MDA-MB-231-luc heterologous tumors in mice. (d) Changes in fluorescence intensity of MCF-7-luc heterologous tumor in mice. (e) Body weight changes of mice with MDA-MB-231-luc allogeneic tumors after tumor cell injection and T cell treatment. (f) Body weight changes of mice with MCF-7-luc allogeneic tumors after tumor cell injection and T cell treatment (n = 4, bar value represents dispersion degree).

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