Engineered IL-7 Receptor Enhances the Therapeutic Effect of AXL-CAR-T Cells on Triple-Negative Breast Cancer

<div>Immunohistochemistry of CD3, Ki67, and granzyme B in mouse tumor tissue. (a) Detection of CD3 on tumor tissue from the MDA-MB-231 xenograft mouse model. (b) Determination of the number of CD3-positive cells by cell counting. (c) Detection of Ki67 on tumor tissue. (d) Determination of the number of Ki67-positive cells by cell counting. (e) Detection of granzyme B on tumor tissue. (f) The positivity of granzyme B staining was analyzed by integrated optical density (IDO) using Image-Pro PLUS v6.0 software. The image was taken at a magnification of ×400. 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BioMed Research International

fig6

Figure 6

Figure 6: Engineered IL-7 Receptor Enhances the Therapeutic Effect of AXL-CAR-T Cells on Triple-Negative Breast Cancer 