miR-21-5p Suppresses Mitophagy to Alleviate Hyperoxia-Induced Acute Lung Injury by Directly Targeting PGAM5

Figure 2

Hyperoxia exposure induced mitochondrial dysfunction during HALI formation. AEC-II cells were isolated from the rats and treated with 500 μM H₂O₂ for 24 or 48 h. (a) Representative confocal microscopy images of JC-1 staining and (b) MitoTracker Red/GFP-LC3 staining of the cells with different treatments were performed. Images showed representative examples from three independent experiments.  μm.

(a)

(b)