BioMed Research International

Review Article

Manual Acupuncture or Combination with Vitamin B to Treat Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

The characteristics of the included trials.


References	Sample size (T/C)	Age (year)	Disease duration (year)	Intervention		Intervention time (days)	Outcome
References	Sample size (T/C)	Age (year)	Disease duration (year)	Treatment	Control	Intervention time (days)	Outcome

Fei 2011	30/30	T: C:	T: C:	Ac	Mec (p.o)	30	(4), (5)
Han 2016	42/42	T: 56.3 C: 56.2	/	Ac	Mec (p.o)+nimodipine (p.o)	56	(1), (2), (3)
Ji 2010	40/40	T: C:	T: C:	Ac	Mec (i.m)	28	(1), (4), (5)
Li 1998	31/22	/	T: 3 weeks–2 years C: 3 weeks–2 years	Ac	VitB₁, B₁₂ (i.m)	30	(1)
Li 2005	30/30	All:	/	Ac	Mec (i.v)	120	(1), (2), (6)
Li 2011	14/14	/	/	Ac+Mec (p.o)	Mec (p.o)	45	(9)
Lu 2016	31/29	T: C:	T: C:	Ac	Lipoic acid (i.v.drip)+alprostadil (i.v.drip)	30	(1), (2), (3), (6), (7)
Pan 2014	42/42	/	/	Ac+Mec (p.o)	Mec (p.o)	90	(1)
Ren 2007	30/30	T: C:	T: C:	Ac	VitB₁, B₁₂ (i.m)	30	(2), (6)
Song 2005	22/20	T: C:	T: C:	Ac	VitB₁₂ (i.m)+VitB₁, B₆ (p.o)	30	(1), (2), (8)
Wang 2007	50/30	T: 55.8 C: 56.1	T: 6.5 C: 7	Ac+VitB	VitB	30	(4), (5), (6), (7)
Wang 2010	34/32	T: C:	T: C:	Ac+Mec (i.v)	Mec (i.v)	28	(2), (3), (6), (7)
Wu 2017	40/40	T: C:	T: C:	Ac+Mec (p.o)	Mec (p.o)	14	(1), (2), (3), (6), (7), (9)
Yan 2007	46/42	T: 46.7-74.98 C: 46.5-75.6	T: 0.8-12.4 C: 0.7-11.8	Ac+Mec (p.o)	Mec (p.o)	90	(1), (2), (3)
Yao 2012	40/40	T: 54.5 C: 53.4	T: 0.67 C: 0.58	Ac	Mec (p.o)+nimodipine (p.o)	28-56	(1), (2), (3)
Zhao 2007	30/30	T: C:	T: C:	Ac	Mec (p.o)	60	(1), (5)
Zhao 2016	30/30	All:	All:	Ac	Mec (p.o)+nimodipine (p.o)	56	(1), (2), (3)
Zuo 2010	40/35	T: 57.6 C: 57.1	T: 8.7 C: 8.5	Ac+Mec (i.v)	Mec (i.v)	28	(2), (3), (6), (7)

Abbreviation: T: experimental group; C: control group; Ac: acupuncture; Mec: mecobalamin; p.o: per os; i.m: intramuscular vitamins; i.v: intravenous injection; i.v.drip: intravenous drip; Vit: vitamin. (1) Clinical efficacy; (2) the MCV of the peroneal nerve; (3) the SCV of the peroneal nerve; (4) the MCV of the tibial nerve; (5) the SCV of the tibial nerve; (6) the MCV of the median nerve; (7) the SCV of the median nerve; (8) the MCV of the ulnar nerve; (9) Toronto clinical scoring system (TCSS).