A Novel Imidazopyridine Derivative Exerts Anticancer Activity by Inducing Mitochondrial Pathway-Mediated Apoptosis
Compound 9i induces apoptosis in human cervical cancer cells. (a) Representative scatter plots showing the distribution of annexin V and PI staining for control- and compound 9i-treated HeLa cells. DMSO was used as a vehicle control. (b) Quantitative analysis of the percentage of apoptotic cells by FACS analysis. Values are represented as the (). Significance was tested by Student’s -test (, versus DMSO-treated cells). (c) Western blot was used to determine the protein level of caspase in DMSO- or compound 9i-treated HeLa cells. The intensity of the bands was measured, and the fold change of the intensity was compared with that of the control and indicated below the bands. The expression of cleaved caspase-9 was statistically analyzed in Figure S2a. Tubulin was used as a loading control. The results were representative of three independent experiments.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.