Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension

Figure 1

Metabolic fates of arginine in the mammalian cells. (a) Arginine is a mutual substrate for arginase and NOS, which are in equilibrium in physiologic conditions. Regularly coupled eNOS utilizes O₂ and arginine to produce NO and citrulline. Arginase, in turn, converts arginine into ornithine and urea. (b) eNOS is uncoupled by substrate deficiency to produce superoxide anion rather than NO, which further diminishes NO availability.

(a)

(b)