The CC Genotype of Insulin-Induced Gene 2 rs7566605 Is a Protective Factor of Hypercholesteremia Susceptible to Mild Cognitive Impairment, Especially to the Executive Function of Patients with Type 2 Diabetes Mellitus

Table 3

Demographic, clinical, and cognitive characteristics of T2DM patients with different genotypes.

	GG (101)	GC (89)	CC (43)
Age (year)	60 (55-67)	60 (53-67)	56 (52-64)	0.210^‡
Female (%)	36 (40.4)	35 (34.7)	20 (46.5)	0.442^§
Education (year)	10 (9-12)	11 (9-12)	10 (9-12)	0.914^‡
BMI (kg/m^2)	24.93 (22.87-27.09)	14.09 (22.08-26.21)	24.62 (23.60-25.88)	0.318^‡
DM duration (year)	10 (6-15)	10 (8-16)	10 (6-15)	0.768^‡
HBP duration (year)	6 (0-16)	3 (0-10)	1 (0-11)	0.230^‡
Smoking (%)	33 (37.1)	36 (35.6)	13 (30.2)	0.737^§
Insulin usage (%)	48 (53.9)	60 (59.4)	28 (65.1)	0.442^§
Metformin usage (%)	56 (62.9)	59 (58.4)	36 (83.7)	0.013^§
HbA1c (%)	8.6 (7.6-10.6)	8.7 (7.8-10.5)	8.6 (7.7-10.2)	0.797^‡
FPG (mmol/l)	7.40 (6.35-10.00)	7.70 (6.61-9.47)	8.00 (6.67-10.20)	0.257^‡
TG (mmol/l)	1.48 (1.03-2.41)	1.52 (0.90-2.67)	1.67 (1.08-2.25)	0.734^‡
TC (mmol/l)				<0.001^†
HDL (mmol/l)	0.93 (1.09-1.31)	1.10 (0.99-1.28)	1.03 (0.87-1.27)	0.341^‡
LDL (mmol/l)	2.96 (2.50-3.70)	2.77 (2.22-3.53)	2.14 (1.76-2.71)	<0.001^‡
ApoA1				0.869^†
ApoB	0.82 (0.71-0.97)	0.81 (0.64-1.01)	0.72 (0.59-0.85)	0.005^‡
LPa	143 (69-285)	149 (79-318)	111 (70-227)	0.339^‡
MoCA	26 (22-27)	26 (24-27)	27 (25-28)	0.027^‡
DST	12 (11-13)	11 (10-13)	12 (11-13)	0.158^‡
VFT	15 (13-18)	16 (14-19)	16 (14-20)	0.123^‡
CDT	4 (3-4)	4 (3-4)	4 (3-4)	0.082^‡
TMTA	61 (50-101)	58 (48-71)	57 (047-79)	0.109^‡
TMTB	160 (119-252)	148 (115-189)	128 (80-195)	0.016^‡
AVLT-IR	17 (14-21)	18 (15-21)	18 (15-23)	0.391^‡
AVLT-DR	5 (4-7)	6 (5-7)	6 (05-8)	0.144^‡
LMT				0.461^†

BMI: body mass index; DM: diabetes mellitus; HBP: high blood pressure; FPG: fasting plasma glucose; TG: triglycerides; TC: total cholesterol; LDL: low-density lipoprotein cholesterol; HDL: high-density lipoprotein cholesterol; ApoA1: apolipoprotein A1; ApoB: apolipoprotein B; LPa: lipoprotein A; MoCA: Montreal Cognitive Assessment; DST: Digit Span Test; VFT: Verbal Fluency Test; CDT: Clock Drawing Test; TMTA: Trail Making Test-A; TMTB: Trail Making Test-B; AVLT-IR: Auditory Verbal Learning test-immediate recall; AVLT-DR: Auditory Verbal Learning test-delayed recall; LMT: logical memory test; MCI: individuals with mild cognitive impairment; Non-MCI: individuals without mild cognitive impairment. The data are presented as (%), the , or the median (interquartile range) unless otherwise specified. ^†One-way ANOVA was employed for normally distributed variables. ^‡The Kruskal-Wallis test was employed for asymmetrically distributed variables. ^§The chi-squared test was employed for categorical variables. .