Antibody-Based Immunotherapeutic Strategies for the Treatment of Hematological Malignancies

Table 1

Clinical applications and side effects of antibody-based immunotherapeutic strategies.

Strategies	Types	Clinical applications	Side effects
Cancer vaccines	DCs	MM, CLL	More frequently systemic flu-like symptoms occurred: fever or painful swelling of the injected lymph node
OV therapies	MV	Leukemia, Burkitt lymphoma, HL, MM	Pneumonia, laryngotracheobronchitis, encephalitis, occasionally leading to death
	RV	MM, Burkitt lymphoma, AML, CLL	Viremia
	VSV	MM, AML, T cell lymphoma	Neurotoxicity
	CV	MM	No serious side effects
mAbs	Rituximab	Low-grade NHL, CD20^+ follicular lymphoma, CLL	Fatigue, neutropenia, back pain
	Ofatumumab	R/R CLL	Infections, cough, diarrhea, anemia, fatigue, fever, neutropenia, dyspnea, nausea, rash
	BV	HL, sALCL	Peripheral sensory neuropathy, neutropenia, fatigue, nausea, diarrhea, fever, upper respiratory infection, vomiting
	Daratumumab	MM	Nasal congestion, cough, allergic rhinitis, throat irritation, dyspnea
	Denileukin diftitox	CTCL	Asthenia, fever, nausea, mild hypotension, flu-like symptoms, myalgias, chills, vomiting
	Nivolumab	HL	Fatigue, infusion reaction, arthralgia, rash
	Pembrolizumab	HL	Pneumonitis, nephrotic syndrome
CAR-T cell therapies	CAR-T19	ALL, DLBCL, B-NHL, CLL	CRS, neurotoxicity, B cell lacking
	CAR-T-BCMA	MM	CRS, neurotoxicity