Value of Liver Regeneration in Predicting Short-Term Prognosis for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure

Table 2

Univariate and multivariate Cox regression analyses of 90-day mortality in the training cohort.

	Univariate analyses			Multivariate analyses
		HR (95% CI)			HR (95% CI)
Age (years)	0.042	1.043 (1.026, 1.061)	<0.001	0.036	1.037 (1.017, 1.056)	<0.001
Gender (male)	-0.045	0.956 (0.540, 1.693)	0.878
TBil (μmol/L)	0.003	1.003 (1.001, 1.004)	<0.001	0.003	1.003 (1.001, 1.005)	<0.001
Cre (μmol/L)	0.010	1.010 (1.008, 1.013)	<0.001	0.008	1.008 (1.004, 1.011)	<0.001
Alb (g/L)	-0.074	0.929 (0.891, 0.968)	0.001	-0.010	0.990 (0.939, 1.045)	0.728
Leukocyte count (×10^9/L)	0.110	1.116 (1.076, 1.157)	<0.001	-0.114	0.892 (0.742, 1.074)	0.227
Neutrophil count (×10^9/L)	0.127	1.136 (1.095, 1.178)	<0.001	0.169	1.184 (0.965, 1.454)	0.105
ALT (IU/L)	0.000	1.000 (0.999, 1.000)	0.053
AST (IU/L)	0.000	1.000 (1.000, 1.000)	0.672
HBeAg positive (%)	0.115	1.122 (0.675, 1.864)	0.657
HBV DNA (log10 IU/mL)	-0.045	0.956 (0.860, 1.064)	0.956
INR	0.775	2.170 (1.802, 2.612)	<0.001	0.525	1.691 (1.333, 2.146)	<0.001
AFP (ng/mL)	-0.004	0.996 (0.994, 0.998)	0.001	-0.003	0.997 (0.995, 0.999)	0.021
HE	-0.163	0.849 (0.559, 1.291)	0.445
Ascites	0.786	2.194 (1.291, 3.727)	0.004	0.307	1.360 (0.739, 2.502)	0.323

AFP: alpha-fetoprotein; Alb: albumin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; Cre: creatine; HE: hepatic encephalopathy; INR: international normalized ratio; TBil: total bilirubin; HR: hazard ratio; CI: confidence interval.