A System Biology-Based Approach for Designing Combination Therapy in Cancer Precision Medicine

Table 1

Overview and brief descriptions of the ABSM elements [28]. The star components are those which hypothesized to be related to individual variability.

Element	Brief description
	The whole number of tumor cells in the tissue at iteration
	The whole number of NA_1 in the tissue at iteration
	The number of IA newborns in the tissue at iteration
	Sum of the numbers of failures in IA fighting against tumor cells till iteration
	The number of NA_1s in the neighborhood of site ()
	The number of IAs in the neighborhood of site ()
()	The average radius of the external edge of the tumor (Figure 10) at iteration
()	The average radius of the necrotic zone (Figure 10) at iteration
	Necrotic fraction ()
	The probability of producing a NA_1 in the site () at iteration
	Maximum allowable time duration to stay in NA_1 mode without proliferation
	The production probability of a NA_1_2 from the mitosis of a NA_1_1
	A whole number of victories of IA in fighting against tumor cells at iteration
	Protumor probability
	Antitumor probability
	NA_1 rim thickness
	Pure tumor growth fraction at iteration
	Growth fraction ()