A System Biology-Based Approach for Designing Combination Therapy in Cancer Precision Medicine

Table 13

Hypothesized relations among model parameters and cancer hallmarks and TME players. Star parameters are assumed to be individuals’ genetic, molecular, or cellular dependency.

Parameter	Representative hallmark	Hypothesized TME player
	1, 2, 4, 6, 7, 8, 9	1, 2
	1, 2, 4, 6, 7, 8, 9	1
	8	2, 6, 5
	1, 2, 3	2, 6, 4, 5
	1, 2, 4, 6, 9	6
max	7	6
	1, 2	6
	1, 2	6
Age	1, 2, 4, 6, 9	6