JMJD1A Represses the Development of Cardiomyocyte Hypertrophy by Regulating the Expression of Catalase

Figure 1

JMJD1A expression is downregulated during cardiac hypertrophy. (a) mRNA levels of hypertrophic fetal genes in the hearts from control or hypertrophic cardiomyopathy (HCM). ANP: atrial natriuretic peptide; BNP: brain natriuretic peptide; MYH7: beta-myosin heavy chain. in each group, vs. healthy group. (b) mRNA levels of JMJD1A in the hearts from control or hypertrophic cardiomyopathy (HCM). in control group, in HCM group, . (c) Protein levels of JMJD1A and H3K9me1/2 in the hearts from control or hypertrophic cardiomyopathy (HCM). (d) mRNA levels of hypertrophic fetal genes in the hearts of mice underwent sham or TAC surgery. TAC: transverse aortic constriction. in each group, vs. sham group. (e) mRNA levels of Jmjd1a in the hearts of mice underwent sham or TAC surgery. in each group, vs. sham group. (f) Protein levels of JMJD1A and H3K9me1/2in the hearts from mice underwent sham or TAC surgery for four weeks. (g) mRNA levels of hypertrophic fetal genes in the hearts of mice underwent saline or ISO infusion for four weeks. in each group, vs. saline group. (h) mRNA levels of Jmjd1a in the hearts of mice underwent saline or ISO infusion for four weeks. in each group, vs. saline group. (i) Protein levels of JMJD1A and H3K9me1/2in the hearts from mice underwent saline or ISO infusion for four weeks.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)