Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway

Figure 1

circ_0026359 was overexpressed in gastric cancer and associated with CDDP resistance and poor survival rates in gastric cancer patients. (a) Expression levels of circ_0026359 in 55 pairs of gastric cancer tissues and normal gastric tissues were examined by RT-qPCR. (b) Expression levels of circ_0026359 in 33 CDDP-sensitive (CS) and 22 CDDP-resistant (CT) gastric cancer tissues. (c) Expression levels of circ_0026359 in normal gastric cell GES-1 and gastric cancer cells HGC-27, AGS, BGC-823, SGC-7901, and MKN-45 were examined by RT-qPCR. (d) Expression levels of circ_0026359 in CDDP-resistant gastric cancer cells SGC-7901/CDDP and MKN-45/CDDP and parental gastric cells SGC-7901 and MKN-45. GAPDH was examined as control for RT-qPCR. (e) Overall survival (OS) rates and (f) relapse-free survival (RFS) rates in gastric cancer patients with high circ_0026359 expression and low circ_0026359 expression were analyzed by Kaplan-Meier curves. ; .

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