Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway
The effect of Polyphyllin I on cell viability. (a) Chemical structure of Polyphyllin I. (b) Polyphyllin I treatment inhibited significantly A375 cell proliferation, but IGF-1 treatment attenuated considerably the inhibitory function of Polyphyllin I in A375 cells growth. in comparison with 0 mg/L PPI group; # in comparison with 6 mg/L PPI group. Note: 1: 0 mg/L PPI group; 2: 1.5 mg/L PPI group; 3: 3.0 mg/L PPI group; 4: 6.0 mg/L PPI group; 5: 6.0 mg/L PPI +20 mg/L IGF-1group.
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