Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway

Figure 3

Polyphyllin I treatment suppressed cell cycle progression of melanoma cells. Polyphyllin I triggered cell cycle blockage in A375 melanoma cells in the G0/G1 phase, but IGF-1 attenuated the inhibitory effect of Polyphyllin I on the A375 cell cycle. Note: 1: 0 mg/L PPI group; 2: 1.5 mg/L PPI group; 3: 3.0 mg/L PPI group; 4: 6.0 mg/L PPI group; 5: 6.0 mg/L PPI +20 mg/L IGF-1group.