BioMed Research International

Research Article

The Diagnostic Accuracy of Combined Enolase/Cr, CA125, and CA19-9 in the Detection of Endometriosis

Table 3

AUC, sensitivity, specificity, PPV, NPV, +LR, and -LR of individual and combined markers for endometriosis.


Marker	ROC-AUC	Sensitivity	Specificity	Positive predictive value	Negative predictive value	Positive likelihood ratio	Negative likelihood ratio
Marker	ROC-AUC	(95% CI)

Enolase-Cr	0.443 (0.317-0.569)	97.8 (88.7-99.9)	13.5 (4.5-28.8)	58.9 (55.94-62.27)	83.3 (36.91-99.26)	1.13 (0.8-52.0)	0.16 (0.1-1.0)
CA125	0.220 (0.117-0.322)	69.5 (54.2-82.3)	86.5 (71.2-95.5)	86.4 (73.37-93.6)	69.5 (59.14-78.23)	5.11 (1.8-5.5)	0.35 (0.08-0.4)
CA19-9	0.359 (0.241-0.476)	27.6 (15.6-42.6)	100 (90.5-100.0)	100 (90.1-100.0)	52.1 (47.74-56.52)	—	0.72 (0.2-1.6)
	0.675 (0.573-0.710)	65 (56.5-72.9)	66.6 (57.1-75.3)	71 (64.69-76.57)	60.1 (53.82-66.28)	1.94 (1.5-5.5)	0.52 (0.4-0.7)

The cut-off values for urinary enolase 1, enolase-Cr, CA125, and CA19-9 were 1181 ng/mL, 0.96 ng/mg Cr, 35 IU/mL, and 37 IU/mL, respectively. Abbreviations: ROC-AUC: areas under the receiver operating characteristic curves.