First Serological Study Revealing High Humoral Response and Evidence for Antigenic Heterogeneity in Leishmania donovani Induced CL in Sri Lanka
Table 6
Clinicoepidemiological correlations with seropositivity in the study populations.
Seroprevalence measured by ELISA
Clinicoepidemiological data
Seropositive count ()
Seronegative count ()
Total count ()
value
Age (years)
≤25
38/49 (77.6)
11/49 (22.4)
49
0.497
26 to 50
96/118 (81.4)
22/118 (18.6)
118
>50
29/33 (87.9)
4/33 (12.1)
33
Sex
Male
133/160 (83.1)
27/160 (16.9)
160
0.257
Female
30/40 (75.0)
10/40 (25.0)
40
Lesion size
Up to 1 cm
34/49 (69.4)
15/49 (30.6)
49
0.044
2-3 cm
89/103 (86.4)
14/103 (13.6)
103
>3 cm
34/42 (81.0)
8/42 (19.0)
42
Number of lesions
One lesion
133/161 (82.6)
28/161 (17.4)
161
0.490
>one lesion
30/39 (76.9)
9/39 (23.1)
39
Duration of lesions
Up to 3 months
46/64 (71.9)
18/64 (28.1)
64
0.017
4 to 6 months
56/61 (91.8)
5/61 (8.2)
61
>6 months
44/55 (80.0)
11/55 (20.0)
55
Type of lesions
Ulcerative#
95/108 (88.0)
13/108 (12.0)
108
0.008
Nonulcerative#
65/89 (73.0)
24/89 (27.0)
89
Site of lesion
Head and neck area
36/54 (66.7)
18/54 (33.3)
54
0.007
Arms
81/94 (86.2)
13/94 (13.8)
94
Other
41/47 (87.2)
6/47 (12.8)
47
Seroprevalence was measured by ELISA at 0.189 cut-off level. Missing data were excluded. #Working definitions: lesions on the skin accompanied by the disintegration of tissue or not were considered as ulcerative (viz., ulcerating nodules, ulcerating plaques, and complete ulcers) and nonulcerative (viz., papules, nodules, and plaques) lesions, respectively.
