The First Asian, Single-Center Experience of Blastocyst Preimplantation Genetic Diagnosis with HLA Matching in Thailand for the Prevention of Thalassemia and Subsequent Curative Hematopoietic Stem Cell Transplantation of Twelve Affected Siblings

Table 4

Details and outcomes of PGD-HLA HSCT.

	Recipient sex	PGD-HLA donor sex and Dx^a	Patient origin	Affected sibling thalassemia mutation diagnosis	HSC source	Recipient age at HSCT (months)	HSCT status/country HSCT performed	HSCT-related complications
1	M	M (normal)	Thailand	BThal/HbE Cd.17 (A>T)/HbE	UCB	59	Success/Thailand	None
2	F	F (HbE trait)	Thailand	BThal/HbE HbE/IVSII-654 (C>T)	UCB	45	Success/Thailand	None
3	F	M (HbE trait)	Thailand	BThal/HbE Cd.41/42 (-TCTT)/HbE	UCB	67	Success/Thailand	None
4	M	F (HbE trait)	Thailand	BThal/HbE Cd.41/42 (-TCTT)/HbE	UCB	39	Success/Thailand	None
5	M	F/F (IVSI-5)	Thailand	BThal/HbE HbE/IVSI-5 (G>C)	UCB twins	56	Success/Thailand	Mild VOD, completely resolved
6	F	F (normal)	Thailand	homoB-thal IVSII-654 (C>T)/Cd.41/42 (-TCTT)	UCB	45	Success Thailand	None
7	M	M (Beta-28)	Thailand	homoB-thal beta-28 (A>G)/Cd.17 (A>T)	UCB in/ex utero collection	36	Success/Thailand	None
8	F	F (HbE trait)	Thailand	B-thal/HbE HbE/IVSII-654 (C>T)	UCB + BM^c (BM donor age 76 months)	202	Success/Thailand	Grade 2 acute GvHD currently regress on cyclosporine and prednisolone. Mild VOD, thrombocytopenia, and CMV reactivation, all completely resolved
9	F	M (normal)	Cambodia	B-thal/HbE HbE/Cd.17 (A>T)	BM^c (BM donor age 12 months) (UCB not used)	132	Success/India	None
10	M	F (normal)	Cambodia	B-thal/HbE HbE/IVSII-654 (C>T)	UCB	Awaiting HSCT
11	F	M (normal)	China	homoB-thal beta-28/Cd.41/42 (-TCTT)	UCB + BM^c (BM donor age 36 months)	108	Success/China	None
12	F	M (normal)	India	homoB-thal IVSI-5 (G>C)/IVSI-1 (G>A)	UCB	60	Success/India	None
13	M	M (carrier)	India	homoB-thal IVSI-5 (G>C)/IVSI-5 (G>C)	N/A^b	Unknown
14	F	M (IVSI-5)	India	homoB-thal Cd.41/42 (TCTT)/IVSI-5 (G>C)	UCB + BM^c (BM donor age at 29 months)	75	Success/Thailand	None
15	F	F (αα/--^SEA)	Vietnam	HbH-CS disease (--/α^Csα)	UCB	Awaiting HSCT

^aDx = diagnosis. ^bN/A = not applicable. ^cSame donor. CMV = cytomegalovirus; VOD = veno-occlusive disease; GvHD = graft-versus-host disease.