Research Article
The Risk of Acute Kidney Injury in Hepatitis B Virus-Related Acute on Chronic Liver Failure with Tenofovir Treatment
Table 1
Baseline characteristics of study population.
| Variable | Unmatched | Matched | ETV group () | TDF group () | value | ETV group () | TDF group () | value |
| Age (years) | | | 0.266 | | | 0.631 | Male, (%) | 42 (75.00%) | 29 (74.36%) | 0.944 | 30 (76.92%) | 29 (74.36%) | 0.792 | Ascites, (%) | 44 (78.57%) | 31 (79.49%) | 0.914 | 29 (74.36%) | 31 (79.49%) | 0.591 | HE, (%) | 9 (16.07%) | 5 (12.82%) | 0.884 | 7 (17.95%) | 5 (12.82%) | 0.530 | Cirrhosis, (%) | 39 (69.62%) | 29 (74.36%) | 0.787 | 26 (66.67%) | 29 (74.36%) | 0.456 | TBIL (mmol/L) | | | 0.396 | | | 0.612 | ALT (U/L) | | | 0.071 | | | 0.354 | AST (U/L) | | | 0.031 | | | 0.200 | Albumin (g/L) | 30.05 (27.85-32.80) | 30.00 (27.90-34.00) | 0.934 | 29.80 (27.40-33.30) | 30.00 (27.90-34.00) | 0.768 | INR | | | 0.249 | | | 0.864 | BUN (mmol/L) | | | 0.052 | | | 0.203 | sCr (μmol/L) | | | 0.474 | | | 0.633 | Cystatin C (mg/L) | | | 0.128 | | | 0.301 | GFR (mL/min) | | | 0.392 | | | 0.650 | HBsAglog10 (ng/mL) | | | 0.595 | | | 0.243 | HBeAg-positive, (%) | 26 (46.43%) | 22 (52.79%) | 0.454 | 19 (48.72%) | 22 (52.79%) | 0.496 | HBVDNAlog10 (IU/mL) | | | 0.560 | | | 0.903 | Na (mmol/L) | | | 0.007 | | | 0.058 | WBC (×109/L) | | | 0.247 | | | 0.510 | HGB (g/L) | 119.07 (102.25-136.50) | 132.67 (119.00-147.00) | 0.011 | 124.00 (111.00-143.00) | 132.67 (119.00-147.00) | 0.147 | Platelets (×109/L) | | | 0.303 | | | 0.820 | CTP score | | | 0.766 | | | 0.694 | MELD score | | | 0.139 | | | 0.928 | MELD-Na score | | | 0.047 | | | 0.593 | CLIF-SOFA score | | | 0.603 | | | 0.852 | Diabetes, (%) | 8 (14.29%) | 3 (7.70%) | 0.508 | 5 (12.82%) | 3 (7.70%) | 0.709 | Hypertension, (%) | 7 (12.50%) | 2 (5.13%) | 0.395 | 4 (10.26%) | 2 (5.13%) | 0.671 |
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HE: hepatic encephalopathy; TBIL: total bilirubin; ALT: alanine aminotransferase; AST: aspartate transaminase; INR: international normalized ratio; BUN: blood urea nitrogen; sCr: serum creatinine; GFR: glomerular filtration rate; HBV: hepatitis B virus; HBsAg: hepatitis B surface antigen; HBeAg: hepatitis B e antigen; WBC: white blood cell; HGB: hemoglobin; CTP: Child-Turcotte-Pugh; MELD: model for end-stage liver disease; CLIF-SOFA: chronic liver failure-sequential organ failure assessment.
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