The Risk of Acute Kidney Injury in Hepatitis B Virus-Related Acute on Chronic Liver Failure with Tenofovir Treatment

Table 5

Cox analysis of risk factors for mortality.

Variable	Univariate analysis (95% CI)	value	Multivariate analysis (95% CI)	value
Age	1.044 (1.010-1.079)	0.011	1.103 (1.038-1.172)	0.002
Male	1.276 (0.360-4.522)	0.706	1.200 (0.277-6.340)	0.830
HE	3.291 (1.123-9.644)	0.030	7.156 (0.740-69.170)	0.089
HBeAg-positive	8.356 (1.884-37.062)	0.005	10.611 (1.314-85.709)	0.027
Cirrhosis	1.253 (0.428-3.667)	0.681	47.232 (5.538-402.802)	<0.001
Antivirus therapy	0.885 (0.321-2.442)	0.814
AKI	1.617 (0.213-12.302)	0.642	5.394 (0.535-54.420)	0.153
lgHBsAg (ng/mL)	0.874 (0.551-1.388)	0.570
lgHBV-DNA (IU/mL)	0.920 (0.687-1.233)	0.577	0.925 (0.563-1.522)	0.760
ALT (U/L)	1.000 (1.000-1.001)	0.407
sCr (μmol/L)	0.985 (0.879-1.104)	0.795
WBC (10^12/L)	0.993 (0.857-1.151)	0.929
PLT (10^9/L)	0.997 (0.988-1.007)	0.598
Meld-Na score	1.107 (1.020-1.201)	0.015	0.972 (0.837-1.128)	0.704
CTP score	1.743 (1.266-2.400)	0.001	1.990 (1.210-3.271)	0.007
SOFA score	2.146 (1.528-3.013)	<0.001	3.000 (1.621-5.553)	<0.001