The Impact of microRNA Regulation on Immune Recovery in HIV-1-Infected Patients Treated during Acute Infection: A Pilot Study

Figure 4

Target genes of differentially expressed miRNAs between baseline and after 24 months of ART. The target genes of the differentially expressed miRNAs between the IR and INR groups at baseline (a), the IR and INR groups after 24 months of maintaining VS (b), at baseline and after 24 months of maintaining VS in the IR group (c), and at baseline and after 24 months of maintaining VS in the INR group (d). Blue columns indicate the target genes involved in biological processes; green columns indicate the target genes associated with cellular components; red columns indicate the target genes involved in cellular activities/functions. VS: virological suppression; IR: immunological responders; INR: immunological nonresponders; BL: baseline; ART: antiretroviral therapy (at least 24 months of ART).

(a) IR vs INR at BL

(b) IR vs. INR on ART

(c) IR: at BL vs on ART

(d) INR: at BL vs. on ART