Putative Genes and Pathways Involved in the Acne Treatment of Isotretinoin via Microarray Data Analyses

Table 3

KEGG pathway enrichment analysis of genes of modules 1, 2, and 3 in the PPI network of GSE11792.

Term	Description	Count	value	Genes
Module 1
hsa01100	Metabolic pathways	12	5.21E-09	SC5D, MSMO1, MVD, HMGCR, DHCR7, FDPS, HMGCS1, MVK, ACAT2, IDI1, NSDHL, FDFT1
hsa01130	Biosynthesis of antibiotics	11	6.70E-15	SC5D, MSMO1, MVD, HMGCR, FDPS, HMGCS1, MVK, ACAT2, IDI1, NSDHL, FDFT1
hsa00900	Terpenoid backbone biosynthesis	7	2.32E-13	MVD, HMGCR, FDPS, HMGCS1, MVK, ACAT2, IDI1
hsa00100	Steroid biosynthesis	5	1.69E-08	SC5D, MSMO1, DHCR7, NSDHL, FDFT1
hsa00072	Synthesis and degradation of ketone bodies	2	0.015886	HMGCS1, ACAT2
hsa00650	Butanoate metabolism	2	0.042368	HMGCS1, ACAT2
Module 2
hsa04146	Peroxisome	9	3.18E-16	ACOX2, PECR, AMACR, HAO2, GNPAT, IDH1, PEX13, CRAT, SLC27A2
hsa00120	Primary bile acid biosynthesis	2	0.01961	ACOX2, AMACR
Module 3
hsa00280	Valine, leucine and isoleucine degradation	6	7.14E-11	ACAA2, DBT, ACADM, HADH, PCCB, ACAA1
hsa01130	Biosynthesis of antibiotics	6	1.55E-07	ACAA2, DBT, ACADM, HADH, PCCB, ACAA1
hsa01100	Metabolic pathways	6	8.88E-04	ACAA2, DBT, ACADM, HADH, PCCB, ACAA1
hsa00071	Fatty acid degradation	4	4.18E-06	ACAA2, ACADM, HADH, ACAA1
hsa01212	Fatty acid metabolism	4	6.29E-06	ACAA2, ACADM, HADH, ACAA1
hsa00640	Propanoate metabolism	3	2.37E-04	ACADM, ECHDC1, PCCB
hsa00062	Fatty acid elongation	2	0.021616	ACAA2, HADH

Notes: Count: the number of DEGs. Abbreviations: DEGs: differentially expressed genes; KEGG: Kyoto Encyclopedia of Genes and Genomes; PPI: protein–protein interaction.