Increased Cytoplasmic CD138 Expression Is Associated with Aggressive Characteristics in Prostate Cancer and Is an Independent Predictor for Biochemical Recurrence

Table 4

Multivariate Cox regression analysis including established prognostic parameters and cytoplasmic CD138 staining in all prostate cancers, in ERG negative and ERG positive subset.

Tumor subset	Scenario	analyzable	value
			Preoperative PSA level	pT stage	cT stage	Gleason grade prostatectomy	Gleason grade biopsy	pN stage	stage	CD138 cytoplasmic expression
All cancers	1	6885	<0.0001	<0.0001	—	<0.0001	—	<0.0001	<0.0001	<0.0001
	2	10372	<0.0001	<0.0001	—	<0.0001	—	—	<0.0001	<0.0001
	3	10214	<0.0001	—	<0.0001	<0.0001	—	—	—	<0.0001
	4	8746	<0.0001	—	<0.0001	—	<0.0001	—	—	<0.0001
ERG negative cancers	1	3221	<0.0001	<0.0001	—	<0.0001	—	<0.0001	0.0158	0.1018
	2	4823	<0.0001	<0.0001	—	<0.0001	—	—	<0.0001	0.0651
	3	4759	<0.0001	—	<0.0001	<0.0001	—	—	—	0.0024
	4	3918	<0.0001	—	<0.0001	—	<0.0001	—	—	<0.0001
ERG positive cancers	1	2615	<0.0001	<0.0001	—	<0.0001	—	<0.0001	<0.0001	0.0108
	2	4053	<0.0001	<0.0001	—	<0.0001	—	—	<0.0001	<0.0001
	3	3980	<0.0001	—	<0.0001	<0.0001	—	—	—	<0.0001
	4	3447	<0.0001	—	<0.0001	—	<0.0001	—	—	<0.0001