Combined Administration of Bisphosphonates, Chemotherapeutic Agents, and/or Targeted Drugs Increases the Risk for Stage 3 Medication-Related Osteonecrosis of the Jaw: A 4-Year Retrospective Study

Table 5

Results of multivariate logistic regression analysis.

Variable	values	Crude OR	Adjusted OR	95% CI
				Lower	Upper
Model 1
Chemotherapy	0.044	4.77	3.43	1.03	11.38
Targeted drugs	0.040	4.22	3.69	1.06	12.80
Maxilla	0.026	4.46	4.26	1.19	15.23
Model 2
Chemotherapy	0.013	—	4.26	1.35	13.40
Maxilla	0.028	—	3.91	1.16	13.19
Model 3
Targeted drugs	0.013	—	4.58	1.38	15.16
Maxilla	0.012	—	4.85	1.42	16.61

The first model contained chemotherapy, targeted drugs, and maxillary lesions. The second model included chemotherapy and maxillary lesions. The third model contained targeted drugs and maxillary lesions. OR, 95% CI, and values were calculated with the conditional multivariate logistic regression models according to likelihood ratio criteria. OR was mutually adjusted for variables in each model. values were statistically significant. Abbreviations: OR: odds ratio; 95% CI: 95% confidence interval.