Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Figure 4

(a) The spheroid growth effect depends on the ratio of ANS-MAs with PTT. Spheroids were irradiated with 810 nm laser light for 10 min at an irradiance of 14 W/cm². The values shown represent the average spheroid diameter 14 days postphotothermal treatment as a % increase of the initial size. Complete growth inhibition was observed at a FaDu : ANS-MA ratio of 4 : 1. (b) Kinetics of spheroid growth following PTT. PTT of spheroids containing ANS-MAs resulted in a decrease in the spheroid volume. In contrast, the untreated spheroids and spheroids containing empty macrophage continued to increase in volume (PTT: photothermal therapy; Ma: macrophage; ANS-MAs: gold nanoshell-loaded macrophages).

(a)

(b)